Everything to Know About Collagen-Boosting Fillers

How do Cell Regenerating Fillers Work?

Radiesse and Ellansé boost Type 1 collagen production, but while Ellansé has always been marketed as a bio-stimulating filler, it's only been recently discovered that Radiesse has the same cell-boosting capabilities. "Developed in the U.S., Radiesse has been used for over ten years," says Dr. Goldie. "Traditionally, it has been used to create and replace volume in the face, but over the years, physicians have innovated and changed the way it is used by looking again at the basics of how it works and using these unique regenerative properties, rather than just as filler." For example, when Radiesse is hyper-diluted and injected into the neck using cannulas, it can instantly smooth crepey neck skin while also stimulating collagen production, so the neck area stays smoother for longer after the filler has dissolved away.

"We now understand from research that Radiesse is so much more than a filler," says Dr. Goldie. "When injected in the tissue, it will create healthy type 1 collagen by up to 30 percent more." She goes on to explain that it promotes the development of elastin, increases blood supply and improves cell turnover. "We have also seen in biopsies that the fibroblasts contract better when Calcium hydroxylapatite (CaHA) found in Radiesse is present—what this looks like is tissue that is not just filled but is firmer and tighter too," she says.

Ellansé, much like Radiesse, produces both instant and gradual results. "Increased volume, contouring and definition occurs immediately post-injection, but the result achieved is maintained due to the production of Type 1 collagen in response to the PolyCaproLactone in the product, stimulating fibroblasts in the areas Ellansé is placed," explains Dr. Manning. "The length of the polymer chain of the PCL is what gives Ellansé its unique longevity properties. It can last from one to four years. The greater the length of the polymer chain, the longer-lasting the product will be."

In comparison, regular hyaluronic acid fillers like Juvederm or Restylane wear off at around six months, while Radiesss lasts 12 to 18 months. What sets Radiesse and Ellansé apart isn't just the fact the filler lasts longer, but that it will stimulate Type 1 collagen production so when it does wear off, depending on where you had it injected, you'll be left with naturally plumper lips or smoother neck naturally.